Cancer does not start on a scan. Long before a tumor is visible, metabolic signaling is already shifting. One of the earliest patterns we see? Insulin resistance. Insulin is not just a blood sugar hormone — it is a growth factor. Chronically elevated insulin: • Activates the PI3K/Akt/mTOR pathway • Increases IGF-1 signaling • Promotes cellular proliferation • Inhibits apoptosis Large prospective cohort studies have linked hyperinsulinemia with increased risk of colorectal, breast, pancreatic, an