A 38-year-old man presented with a 15-year history of a waxing and waning rash on his palms and soles. A skin biopsy revealed dense lymphocytic infiltration of the superficial and middle dermis.

In the KEYNOTE-522 trial, neoadjuvant and adjuvant pembrolizumab improved pathological complete response and event-free survival among patients with early-stage triple-negative breast cancer.

Pneumococcal conjugate vaccines are highly effective in reducing vaccine-type pneumococcal disease but are expensive. Fractional-dose vaccines may help sustain vaccine programs. New research ...

Nivolumab, a PD-1 inhibitor, and ipilimumab, a cytotoxic T-lymphocyte antigen 4 inhibitor, are immune checkpoint inhibitors with complementary mechanisms of action, which might enhance antitumor ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Panel A is a map of the communes in Nha Trang showing the trial-group assignment in each commune (no vaccination, 0p+1, 1p+1, 2p+1, or 3p+0). Panel B shows the percentages of infants (children 4 ...

Of the 153 enrolled patients, 127 (83.0%) received at least one infusion of obe-cel and were evaluable. In cohort 2A (94 patients; median follow-up, 20.3 months), overall remission occurred in 77% ...

Twice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy of lenacapavir for preexposure prophylaxis (PrEP) in ...

Dr. Lara Basovic: A 41-year-old man was admitted to the epilepsy monitoring unit (EMU) of this hospital because of seizures. When the patient was 4 years of age, his mother noticed an episode of ...