Background: Cardiovascular disease caused by atherosclerosis is responsible for 18 million deaths annually, highlighting a significant need for new medical therapies, especially for patients who are ...

The rapid development and integration of artificial intelligence (AI), including predictive, generative, and emerging agentic ...

Introduction: There is increasing use of digital health solutions in heart failure (HF), but few studies have demonstrated its impact on public healthcare systems in North America. The Continuum ...

Background: Metformin is not FDA-approved for prediabetes but it is being prescribed off-label for this condition. Per the American Diabetes Association (ADA), metformin “should be considered” for ...

At 19 years of age, a woman experiencing dyspnea on exertion was diagnosed with idiopathic pulmonary arterial hypertension. Pulmonary arterial hypertension–targeted drugs (oral beraprost, sildenafil, ...

A 68-year-old man presented to the emergency department with sudden-onset chest pain, which had been persistent for 8 hours. He had been experiencing exertional shortness of breath in the preceding ...

Coronary angiography remains an important modality to assess atherosclerotic coronary artery disease and to guide percutaneous coronary intervention. Intravascular ultrasound (IVUS) is an important ...

The BNT162b2 mRNA (Pfizer-BioNTech) and mRNA-1273 (Moderna) coronavirus disease 2019 (COVID-19) vaccines have gained widespread use across the globe to prevent further spread of severe acute ...

Introduction: Eicosanoids play an important role in regulating inflammation response, which influences the development of heart failure (HF). However, the association between eicosanoids and the risk ...

Background: The association between specific types of fat intake and the risk of stroke remains inconclusive. Prospective data examining the relation of fat from different food sources to stroke risk ...

A 46-year-old man with a history of neurosarcoidosis presented to the emergency room with nonradiating, midsternal chest pressure with associated dyspnea lasting for 10 minutes that occurred 1 day ...

In the article by Lip et al, “Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients: The ARISTOPHANES Study,” which was published online on November 8, 2018, ...