This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...

Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...

This work will be of high interest to a broad swathe of scientists studying native macromolecules present at low concentrations in cells. Cryo-EM single-particle analyses typically require target ...

During rest and sleep, memory traces replay in the brain. The dialogue between brain regions during replay is thought to stabilize labile memory traces for long-term storage. However, because replay ...

This compelling study is a splendid advance in approximately doubling the number of sequenced chiton genomes, providing what appears to be among the best genome annotations for chiton genomes ...

The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...

Kokumi refers to the enhanced and more delicious state of food flavor. However, the underlying neuroscientific mechanisms remain largely unexplored. Our previous research demonstrated that ornithine ...

Mice can generate a cognitive map of an environment based on self-motion signals when there is a fixed association between their starting point and the location of their goal.

We can now collect cell-count data across whole animal brains quantifying recent neuronal activity, gene expression, or anatomical connectivity. This is a powerful approach since it is a multi-region ...

Astrocytic ER calcium release and gap junction communication exhibit circadian modulation driven by HERPUD1, highlighting the importance of astrocytic circadian rhythms in brain function.

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, United States ...

WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...