In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

Mike Tirico and Jason Garrett destroyed a young Green Bay Packers fan for his hilarious sign during the Thanksgiving game.

The Thanksgiving Night Game will have big playoff implications as the Green Bay Packers will host the Miami Dolphins at Lambeau Field at 8:20 pm ET.

In last week’s 38-10 blowout loss to the Green Bay Packers, the 49ers’ loss had little to do with the weather at Lambeau ...

ORCHARD PARK, N.Y. — The Buffalo Bills have announced their uniform combination for their Sunday Night Football game. The Bills on social media on Wednesday said they will don their traditional white ...

All-Pro linebacker Matt Milano and breakout rookie receiver Keon Coleman both practiced for the Bills on Wednesday. Milano ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

Matt Maiocco shares the latest practice report for the San Francisco 49ers and Buffalo Bills ahead of their Week 13 game on ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The 49ers listed Brock Purdy as a limited participant while Nick Bosa and Trent Williams were among those not practicing ...