In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

The NFL playoff picture isn't moving much after Thanksgiving, but some teams can seal the first postseason berths in Week 13.

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...