A hallmark of Parkinson's disease is the buildup of Lewy bodies—misfolded clumps of the protein known as alpha-synuclein.

Malaria kills over 600,000 people a year, and as the climate warms, the potential range of the disease is growing. While some drugs can effectively prevent and treat malaria, resistance to those drugs ...

Transport proteins are responsible for the ongoing movement of substrates into and out of a biological cell. However, it is difficult to determine which substrates a specific protein can transport.

The Golgi apparatus transports and modifies proteins in eukaryotic cells. How have scientists studied dynamic protein movements through the Golgi? One of the principal observations by Rothman's group ...

This illustration shows how the membrane trafficking protein VAMP72 gradually changed during plant evolution to give rise to VAMP727, which functions in transporting storage proteins to vacuoles. The ...

Botanists have come to understand the channels and transporters involved in the uptake and transport of nutrients, yet how are they positioned where they need to be? For example, plants need boron, ...

Grapevine CCC protein (in two nearly orthogonal orientations) transports potassium (purple) and chloride (green) ions through the pore (black dots) in an electroneutral fashion. Researchers at the ...

Scientists led by Julia Sacher from Max Planck Institute for Human Cognitive and Brain Sciences and Osama Sabri from the Leipzig University Hospital have discovered in an elaborate patient study that ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...