Reverse transcriptase is responsible for converting viral RNA into DNA via its dual functions – the DNA polymerase and RNase H activities – making it an attractive and multifaceted target.

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) comprise approximately 10% of the HIV drug market worldwide, and efavirenz leads this class with $680 million annual sales in the United ...

Recently, the research team led by Min Wang at the College of Marine Life Sciences, Ocean University of China, published a study titled " Diversity of reverse-transcriptase-containing viruses ...

Through rational structure-based drug design, ROME identified novel, selective and potent inhibitors of LINE-1 reverse transcriptase.

Use of nucleoside reverse transcriptase inhibitors (NRTIs) is associated with a significantly lower risk of developing Alzheimer disease (AD), according to findings published in Alzheimer’s & Dementia ...