Protein activity can be precisely regulated via subtle changes in temperature using heat-sensitive switches. Underlying this ...

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for ...

A new study discovers how nitric oxide triggers a biochemical domino effect in the brain, leading to mTOR overactivation in ...

Neurodegenerative disorders such as Alzheimer's disease (AD) are typically diagnosed after irreversible pathology has developed. Aging, the strongest risk factor, drives molecular changes that ...

A receptor involved in normal physiological processes may also drive breast cancer growth when overexpressed.

HYDRACs are a class of proteomimetic polymers designed to mark harmful proteins, like MYC and KRAS, for destruction rather than merely block their activity.

When cancer-driving proteins resist various treatments, Northwestern University scientists have uncovered a new solution. Don ...

Stay up to date on the latest science with Brush Up Summaries. Finally, although transgenic animals and mammalian cell culture systems promote optimal expression due to correct protein modifications, ...

Targeted protein degradation tricks the internal machinery of cells in weeds to destroy proteins that are essential to their survival.