As a molecular biologist, I always enjoy reading articles concerning DNA and RNA. Your excellent article in the April 3, 2023, issue of C&EN (page 18) titled “The Promise of Peptide Nucleic Acids” ...

Peptide nucleic acids (PNAs) are synthetic analogues of natural nucleic acids, distinguished by a peptide‐like backbone that confers unique binding affinities and high stability against enzymatic ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Triplex gene editing relies on binding a stable peptide nucleic acid (PNA) sequence to a chromosomal target, which alters the helical structure of DNA to stimulate site-specific recombination with a ...

This study introduces a novel signal amplification method induced by aggregation, which achieves specific recognition and sensitive detection of two cancer biomarkers through the rational design of ...

When disease outbreaks happen, response time in developing and distributing treatments is crucial to saving lives. Unfortunately, developing custom drugs as countermeasures is often a slow and ...

The pharmaceutical industry is equipping itself to target genetic defects directly. The pioneer generation of genetic medicines demonstrated the viability of the approach, but their applicability was ...

Nature is the ultimate inspiration for innovators, including those who would emulate biology to realize applications in the life sciences. Indeed, some of the most intrepid innovators are those who ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...