The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.

CONFLICT ENTERS FOURTH DAY: Israel and Iran have begun a new round of attacks, as the conflict between the two heavily armed rivals enters its fourth day.

Israel unleashed airstrikes across Iran for a third day and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country.

After striking back on Friday night, Iran launched a new wave of strikes toward Israel on Saturday morning. Now, the two countries continue to exchange deadly missiles and threats, with fatalities and injuries reported on both sides.

Stocks are down on Friday, with oil prices surging in the wake of the Israel's military strike on Iran. The S&P 500 slid 48 points, or 0.5%, to 5,998 points in early trading, while the Dow Jones Industrial Average dropped 559 points,

President Donald Trump is urging Iran to make a nuclear deal now that Israel has launched strikes against the country.

In all, at least 20 senior commanders were killed, two regional sources said. The head of the Revolutionary Guards aerospace force was also reported to be among them.