It’s too soon to tell how exactly the current wave of Israeli strikes could transform the region, but one thing is clear: Israel’s actions have fundamentally reshaped the security landscape of the Middle East.

Israeli strikes hit Tehran, Mashhad, Shiraz, and Isfahan as casualties in Israel mount and Iran warns of a “more severe” retaliation.

Iran is planning to 'give a harsh response' to an Israeli attack launched early on Friday against its nuclear programme, an Iranian security source told Reuters.

In all, at least 20 senior commanders were killed, two regional sources said. The head of the Revolutionary Guards aerospace force was also reported to be among them.

The death toll is growing as Israel and Iran exchanged missile attacks for a third consecutive day on Sunday, and Israel is warning that worse is to come. Israel targeted Iran's Defense Ministry headquarters in Tehran and sites it alleged were associated with Iran's nuclear program,