Cain has been slowed by elbow and hamstring trouble in recent years. He's 3-11 with a 5.66 ERA this season in 26 games, 22 of them starts for the last-place Giants.

San Francisco Giants pitcher Matt Cain will make his final major-league appearance Saturday. After that, Cain is done with baseball. The 32-year-old announced he would retire at the end of the season.

Cain posted a 1.02 ERA during his senior season at Houston High School, striking out 83 batters in 62 innings. The Giants took him with the 25th pick in the 2002 MLB draft.

As a veteran pitcher, San Francisco Giants righty Matt Cain has practically done it all: make the All-Star team, win a World Series, throw a perfect game. However, he's on the cusp of doing ...

Giants pitcher Matt Cain threw 30 pitches off a bullpen mound Friday, and is scheduled for another session on Tuesday. Although the Giants aren't providing a timetable for his return, Cain has yet ...

Cain and the Giants agreed Monday to a $127.5 million, six-year contract, the largest deal for a right-handed pitcher in baseball history. "This is a decision that was made pretty simple for us.

San Francisco Giants pitcher Matt Cain celebrates after the final out of the ninth inning of a baseball game against the Houston Astros in San Francisco, Wednesday, June 13, 2012. Cain pitched the ...

Giants pitcher Matt Cain was pulled because of right hamstring tightness before the start of the seventh inning in San Francisco's 2-1 victory over the Dodgers on Monday night.

Cain’s 330 starts so far rank second only to Juan Marichal’s 446 in San Francisco history, and yet his name might not come up right away among the great Giants pitchers of recent vintage.

This is an exciting day for Giants fans everywhere and a fantastic way to kick off the 2012 season.” Cain, 27, was 12-11 with a 2.88 ERA, 1.08 WHIP and 179 strikeouts in 221 2/3 innings.

San Francisco Giants pitcher Matt Cain, left, celebrates with catcher Buster Posey after the final out of the ninth inning of a baseball game against the Houston Astros in San Francisco, Wednesday ...