The extracellular matrix (ECM) regulates many cellular functions, and its remodelling by enzymes such as metalloproteinases has a crucial role during development, as exemplified by intestinal, lung, ...

Rhobo6, a light microscopy probe, gives scientists an unprecedented look at the extracellular matrix -- the collection of organized molecular structures that fills the spaces between cells in our ...

A groundbreaking study led by Children's Hospital Los Angeles has found a novel mechanism behind neuroblastoma progression: the shape and structure of the extracellular matrix. The study, led by ...

You can regrow damaged skin in the area, sure—but also bone, tissue, and nerves.

New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ ...

Cancer cells growing in three-dimensional (3D) space encounter unique cell-to-cell interactions, mechanical constraints, and variable access to nutrients, oxygen, and other soluble factors that can ...

Texas A&M University biomedical engineering researchers have developed a treatment for chronic diabetic ulcers using ...

Despite its compact structure—composed of only three amino acids—this endogenous tripeptide has been repeatedly situated at the intersection of regenerative biology, extracellular matrix dynamics, ...

Fascia of live mouse pancreas, in which the extracellular matrix is labeled with Rhobo6 (red) and nuclei are labeled with Hoechst (cyan). Maximum intensity projection shown. Before arriving at Janelia ...