This article serves as your comprehensive guide to endotoxin testing—covering key principles, methods, and best practices.

Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

New standards may help push more drugmakers to use a synthetic product for critical drug safety testing, instead of one made from horseshoe crab blood that has long drawn criticism. The U.S.

Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for quality assurance testing. Credit: Courtesy of Tim Cernak At a recent meeting of the Parenteral Drug ...

STEMart now offers Rapid Endotoxin Testing services for the rapid quantitative analysis of endotoxins to help manufacturers make fast, reliable decisions about the safety of medical devices. The ...

Hundreds of thousands of horseshoe crabs are used for endotoxin testing in the United States each year, bled for their blood’s ability to clot in the presence of toxins. An estimated 10 to 30 percent ...

Charles River International Laboratories, Inc. CRL recently launched Endosafe Trillium rCR cartridges, which combine its hallmark Endosafe cartridge technology with recombinant cascade reagent (rCR).

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...