Oestrogen-induced DNA damage drives genomic instability in BRCA1 mutation cells, with dietary compounds showing protective potential.

Patients with this genetic disorder have a form of dwarfism — they are short in stature and have underdeveloped ears and ...

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

New research has found that oestrogen-induced DNA damage in individuals carrying BRCA1 mutations may play a crucial role in the initiation of cancer, while also pointing to a potential dietary ...

If they happen to do this just before the two DNA strands are cleaved as part of the cell replication process, the protons can become trapped on the wrong side, leading to a DNA mismatch and a ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Johannes holds an MSci in Neuroscience from King’s College London, where he worked on projects involving Alzheimer’s disease and Fragile X syndrome. Johannes holds an MSci in Neuroscience from King’s ...

Researchers discover unexpected patterns in mutation risks across individuals, uncovering 13 distinct genomic patterns. The study provides crucial insights into cancer evolution, identifying the genes ...

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...

Mutations are changes in the molecular "letters" that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including ...