Is Brandon Aiyuk done in San Francisco? Jay Glazer shared why the wide receiver is on thin ice with the 49ers.

Although the 49ers are still hoping that Aiyuk can return in 2025, he has yet to be cleared to do so. The 27-year-old recently returned to the limelight when the team reportedly voided his contract, but that does not indicate any intentions of moving on, according to NFL insider Mike Garafolo.

The San Francisco 49ers have transformed their offense since acquiring Christian McCaffrey from the Carolina Panthers three years ago.

Since the trade on October 20, 2022, the Carolina Panthers have gone 19-37, the sixth-worst record in the NFL. On the other side, the 49ers have gone 35-21, sixth-best record in the NFL, including 4-2 in the playoffs and a Super Bowl appearance.

The San Francisco 49ers have signed kicker Matt Gay to their practice squad to replace Eddy Pineiro, and life's been hectic for Gay recently.

Jason Pinnock was benched after Week 5, but he has played 80 snaps in the 49ers' dime look since then. However, he has not been good in that role. Pinnock allowed five catches, including a touchdown, in his expanded role against the Arizona Cardinals. That should signal a time to switch things up, as he was one of the few issues in that game.

The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.

Our favorite Panthers vs. 49ers prop picks for Monday Night Football are highlighted by star TE George Kittle.

The San Francisco 49ers have a big game against the Carolina Panthers that will swing the playoff odds in a big way, depending on who wins. San Francisco is favored, mostly because the Panthers' passing game is limited. If the 49ers want to win, they essentially just have to shut down one player.