Global air traffic has been disrupted following Israel’s strikes on Iran Friday, with several major airlines suspending flights to and from locations in the Middle East and rerouting their planes to avoid much of the region’s airspace.

Airlines steered clear of much of the Middle East on Friday after Israeli attacks on Iranian sites forced carriers to cancel or divert thousands of flights in the latest upheaval to travel in the region.

The attacks marked the most significant blow to Iran’s military leadership in recent history, with the country losing its two top commanders — Bagheri and Major General Hossein Salami, commander of the elite Islamic Revolutionary Guard Corps — in a single day.